In central, eastern, and western sub-Saharan Africa, the share of disease burden attributable to childhood underweight, household air pollution from solid fuels, and suboptimal breastfeeding has fallen sub stantially. However, these risk factors continue to be the leading three causes of disease burden in 2010. The disease burden attributable to risk factors for childhood communicable diseases, such as micronutrient deficiencies and unimproved water and sanitation, has decreased, both as a proportion of total disease burden and in their rank order: risk factors for some non-communicable diseases and injury accounted for a larger disease burden in 2010. The most notable of these factors were alcohol use and high blood pressure (appendix).