complex pathways by which risk is communicated from the genome to an individual’s clinical status. By being more closely associated with genetic variation, endophenotypes are theorized to be more reliable and reflect larger magnitude relationships, making them easier to detect and replicate in smaller samples. Furthermore, by clarifying the pathophysiological and motivational processes that contribute to the clinical condition, endophenotypes have the potential to provide the foundation for implementing genetically-informed treatment or prevention.
