studies for hepatocellular carcinoma (Kato et al., 1995; Lee et al., 1997; Wong et al., 2000). Many CYP2E1 association studies did not detect an association because the c2 risk allele is rare in Caucasians (2–3%) (Kato et al., 1992; Pastorelli et al., 2001) and African Americans (0.3–7%) (Kato et al., 1992; London et al., 1996; Wu et al., 1997), but much more common for Asian (24–30%) (Lee et al., 1997; Tan et al., 2000; Watanabe et al., 1990) and Mexican American populations (15%) (Wu et al., 1997).
