only in liver cells (this would account also for other organs). This would open the possibility to analyze the disease controlled with mutation-free skin fibroblast from the same patient [37]. It has been published that the reprogramming speed of hepatocytes is faster compared to fibroblasts, blood cells, or bone marrow cells [37]. Another group describes the reprogramming of analogous human pancreatic islet beta cells to iPSCs that can be easily differentiated into insulin-producing cells. This differentiation method, independent from the cell source, may give new possibilities in the treatment of diabetes. However, the reprogramming of this starting material shows an extremely low efficiency (0.0001%) [31].
