The T1 structural MRI data of subcortical volumes (FIRST, n = 14), regional gray matter volumes (FAST, n = 139), and genotypes for 21,402 subjects were downloaded from UKB [44]. The \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{{\hat{\mathrm \Psi }}}}$$\end{document}Ψ^ of the ELOVL7 skipped exon was imputed for each subject and the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{{\hat{\mathrm \Psi }}}}$$\end{document}Ψ^ was regressed against each of the FIRST and FAST volumes. The regression was conducted using generalized linear model (GLM) with Gaussian (log link function) and adjusted for three covariates: sex, age and education score specified by UKB [45]. FDR values of significant changes in the volumes were mapped to the Desikan-Killiany atlas [46] to visualize the regions of interest.
