in the regulation of anxiety, stress, and reward-related behaviors (Dabrowska et al., 2011, Gimpl and Fahrenholz, 2001, Veinante and Freund-Mercier, 1997, Martinon and Dabrowska, 2018). Oxytocin was also found to directly attenuate stress-induced synthesis of CRF within PVN via specific intracellular signaling pathways (Knobloch et al., 2012). These OXT-CRF interactions, especially within the PVN and extended amygdala, are likely play a critical role stress reactivity related to relapse.
