For the primary analysis, individuals were included regardless of cannabis exposure. As secondary analyses, individuals who reported never having used cannabis were excluded, and the primary model was repeated adjusting for the criterion counts for AD, CD, and OD. Participants from 2 genotyping batches in the Yale-Penn cohort (Yale-Penn 1 and Yale-Penn 2) were combined with the SAGE sample to form a discovery data set. A sample consisting of the ICGHD data and additional samples from the Yale-Penn cohort who did not undergo genotyping at the time of the discovery analyses (Yale-Penn 3) were used to replicate the top associations.
