In addition to improved drug grouping, we have added interaction grouping, linking together interaction claims from multiple sources that describe the exact same drug–gene interaction. The grouping efficiency for interactions is 75.2%. The successful grouping of an interaction claim is dependent on the associated gene claims and drug claims successfully grouping. As a result, interaction grouping percentages are closely related to the grouping percentages for drugs and genes (Supplementary Figure S2). The introduction of interaction groups has led to a noticeable improvement in response times on the UI for interaction searches, even when query sizes and result sizes grow larger (Figure 2). Before interaction groups were created, searches in 2.0 had to query almost twice as many database tables as in 3.0. Interaction groups allow for more efficient queries, which leads to a 14-fold reduction in response times when searching the DGIdb.
