Additional tests of aggregate genetic influences did not yield significant findings. The absence of association between PRS derived from meta-analysis and ALSPAC-specific SNP weights and SRE scores in independent samples could be due to assessment, i.e., recall bias within the older individuals in the samples. However, we cannot rule out the possibility that the signals from our GWAS were of insufficient precision for outcome prediction, or that non-genetic factors are simply more influential than genetic factors on initial alcohol sensitivity.
