We filtered out variants with low-quality imputation scores (R2 < 0.8) and removed variants with (1) MAF < 0.05, (2) missing call frequencies > 0.1 or (3) Hardy–Weinberg equilibrium P < 1 × 10−10 using PLINK2 (v.2.00a3LM)58. We then merged the imputed genotypes across four genotyping platforms based on overlapping filtered imputed variants. This resulted in 6,225,756 and 6,097,532 common variants for Black and non-Hispanic WA donors, respectively.
