Chunk #15 — MATERIALS AND METHODS — Electrophysiology analysis — Input conductance

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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

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The input conductance was calculated around the resting membrane potential by measuring the current with the cell held in voltage clamp mode first at −70 mV and then at −50 mV. The difference in currents divided by the difference in membrane potential (of 20 mV) is the calculated input conductance.