The mean AGES for active and placebo groups combined was similar in Studies 1 and 2. However, AGES was lower in the active treatment group (4.1; SD = 1.4) compared to the placebo group (4.4; SD = 1.3) (p = 0.02) in Study 1, while there were no significant differences in mean AGES between active (4.3; SD = 1.4) and placebo (4.4; SD = 1.4) groups in Study 2. Missing genotype data ranged from 0–20% for Study 1 and 3–13% for Study 2. None of the genotypes deviated from Hardy-Weinberg equilibrium except for COMT rs4680 in Study 2 (48).
