underlying the initiation of alcohol use. In distinction to our findings on altered frontostriatal connectivity, young adults at risk for alcohol dependence have been reported to exhibit altered functional connectivity between the accumbens and non-PFC regions such as the precuneus and supplementary sensorimotor area [55]. Together, these findings suggest that response in reward-related neural regions could differ for those with a family history of alcohol dependence but the absence of current problems. In contrast, rather than being a trait-like characteristic or precursor, altered functional connectivity between PFC and accumbens might instead emerge with the process of addiction.
