had been exposed to high childhood trauma, carriers of either the CRHBP rs7728378 major homozygote or the FKBP5 rs3800373 major homozygote had suicide attempt rates of 0.31–0.35 respectively but this rate was almost double (0.58) in individuals who carried both major homozygotes. In contrast, trauma-exposed individuals who carried neither major homozygote had the same suicide rate (0.24) as individuals not exposed to childhood trauma.