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Chunk #6 — The case for pursuing an internalizing pathway to SUDs

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An internalizing pathway to alcohol use and disorder.
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anxiety) in men with versus men without alcohol use disorders, although comorbidity rates of negative affect and substance use disorders remain higher in women (Kessler, Crum, Warner, & Nelson, 1997). Moreover, Depressive Alcoholism was posited to be of late-onset (Cloninger et al., 1996) and thus not of central interest to studies of adolescents and young adults, the period targeted by most research on the development of SUDs. However, recent findings are inconsistent concerning whether the age of onset for SUDs differentiates Antisocial and Negative Affect SUDs as once supposed (e.g., Epstein, Labouvie, McCrady, Jensen, & Hayaki, 2002; Gratzer et al., 2004; Radouco-Thomas, Boivin, Chabot, & Marquis, 1986).