multiple testing correction. Gene signature pattern recognition was performed using Quality Threshold (QT) clustering algorithm with minimum similarity set to 0.95 and minimum cluster size set to 10 genes. Genes comprising each cluster were grouped into functionally significant clusters and biological pathways using the PANTHER (Protein ANalysis THrough Evolutionary Relationships) Classification System (Thomas et al., 2003). All differentially expressed gene lists referred to in this study will be available for viewing online as supplemental data at the following address.
