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Chunk #60 — DISCUSSION

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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.
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the control group from the ‘hypo’ to the ‘hyper’ types and an ~ 2-fold change in the LR and NR groups, indicating that the fast AHP was an important determinant of cell hyperexcitability. This lower change in fast AHP in the BD neurons suggested that BD neurons were already primed for the next action potential through fast recovery from sodium inactivation.