In a small genome-wide association study (GWAS) plus follow-up in Koreans, rs1229984 (ADH1B*2) gave by far the strongest association with AD (OR = 0.42; p = 2.6×10−21), and once conditioned on rs1229984, no other associations in the region remained significant (Park et al., 2013). In a GWAS among methamphetamine dependent subjects and users in Thailand, rs1229984 was associated with the count of DSM-IV AD symptoms (p = 2.7×10−5) (Gelernter et al., 2018). Rs1229984 was associated with drinking vs. non-drinking in Japan (OR = 1.20, P < 3.6 × 10–4) (Takeuchi et al., 2011). Surprisingly, the East Asians in a US study did not show a significant effect of ADH1B*2 on alcohol consumption (Jorgenson et al., 2017), perhaps due to low overall consumption.
