Understanding the dynamics of how genes and developmental trajectories interact to shape AUBs could point to critical time points in which interventions would be most effective, as well as improving our understanding of the mechanisms driving the statistical associations observed in GWAS. In this study, we leverage longitudinal samples to investigate the dynamic effects of genes on AUBs across the lifespan, from early adolescence to middle and older adulthood. Using polygenic scores (PGSs), we examine how the aggregate genetic influences representing diverse EXT- and AUB-related processes shape trajectories of alcohol use across multiple environmental contexts.
