There are four important considerations of the information content of a polygenic score, and how it can be interpreted: The known information, which shows where an individual lies compared to others on the risk scaleThe unknown information from incomplete genetics or unmodelled environmentThe potential for incorrect information, for example, where the individual differs from characteristics of the research study used to estimate the effect size of each genetic variant by genetic ancestry, age, environmental load, or disease definition, or where there is a technical bias in data collectionThe intended use of the PRS, for example, more complete information would be required for justifying a pharmacological intervention than for using the PRS to motivate behaviour change
