Among the genes that show significant phospho-CREB binding after chronic cocaine are many that have previously been implicated in cocaine and CREB action, such as Pdyn, Fos (c-Fos), Nrgn (neurogranin), and Grin2A (Carlezon et al., 1998; Hemby et al., 2005; McClung and Nestler, 2003; Zhang et al., 2006), among other examples given in Fig. 2B, Table 1, and Supplemental Table S9. For each gene promoter illustrated in Fig. 2B, the figure shows where phospho-CREB binding is enriched relative to the gene’s transcription start site and the location of the nearest consensus CRE site (TGACGTCA) or near-consensus site (1 bp different).
