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Chunk #24 — Discussion

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Prediction of alcohol use disorder using personality disorder traits: a twin study.
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Previous studies have indicated that the 10 DSM-5 PDs are associated with AUD, especially ASPD and BPD [1,17,18,20,23]. Our results add to the literature suggesting that (i) the criterion #8 of ASPD (ASPD CD; i.e., childhood conduct disorder), and the criterion #4 of BPD (BPD 4; self-harming impulsive behaviors) are the foremost correlates of AUD among all the 80 criteria for all the 10 PDs, and (ii) that predictive models using just these two criteria superseded those using the full ASPD and BPD diagnoses. Furthermore, it was found that (iii) the two criteria may have distinct biometric structure as risk factors of future AUD: BPD 4 predicted future AUD over the 5–15 years (10-year follow up and 5-year diagnostic window) mainly due to their shared genetic factors, whereas ASPD CD had both genetic and environmentally mediated effects on future AUD.