rodents. ERK activation ultimately results in increased protein synthesis. Inhibition of protein synthesis using systemic anisomycin during long-term memory retrieval also impairs reconsolidation of cocaine44 and morphine CPP.54 In addition to CPP reconsolidation, ERK activation is crucial for the reconsolidation of other forms of memory. Inhibition of MEK with U0126 injections into the lateral nucleus of the amygdala inhibits reconsolidation of auditory fear conditioning.55 Intracerebroventricular injection of U0126 inhibits reconsolidation of object recognition.56
