Group analyses were performed for the correlation maps of each seed ROI. First, these maps were transformed to the Talairach space (re-sampled voxel size: 3×3×3 mm) according to the spatial transformation between the anatomic data and the Talairach space. Second, using AFNI, voxel-wise one-sample t-tests and two-sample t-tests were calculated to compare the seed-based functional connectivity within and between the two groups. For the one-sample t-tests, the correlation maps for each participant in the group (HU or CN, respectively) was entered into the analysis and the z-scores at each voxel were averaged across all participants in the group and compared to zero. Clusters with z-scores significantly larger than zero were determined by combining individual voxel threshold of p < 0.005 with a spatial cluster (cluster size from 29 to 48 voxels among seeds and groups) which yielded a false-positive level of 0.05 over the entire volume according to Monte Carlo simulations conducted with AFNI. For the two-sample t-tests, the correlation maps from both groups were entered into the analysis and the z-scores at each voxel were averaged within each group
