cycle, adhesion, cell projection, mitogen-activated protein kinase, cAMP response element-binding protein, and neurotrophin and neuregulin signalling155. In the same model, cocaine exposure was associated with the down-regulation of several microRNAs, which are involved in post-transcriptional regulation of gene expression in the brain156. RNA transcriptomic analyses in iPSC-derived human neural cells revealed that tetrahydrocannabinol (THC) administration, either by acute or chronic exposure, dampened neuronal transcriptional response following potassium chloride-induced neuronal depolarization with significant alterations to synaptic, mitochondrial and glutamate signalling157.
