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Chunk #22 — METHODS — Meta-analysis and fine-mapping with GIANT and UKB50k. — Fine-mapping.

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Genetic analyses of diverse populations improves discovery for complex traits.
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We used FINEMAP44 for all fine-mapping analyses. For each previously reported locus for height24 and BMI23 in GIANT, a 1-Mb region was subset, using the summary statistics from GIANT, the PAGE + GIANT meta-analysis and the UKB50k + GIANT meta-analysis. The linkage disequilibrium for the fine-mapping analyses was calculated using each individual ancestry from the PAGE sample and using the 9,700 individuals of European descent from the ARIC study. For weighted linkage disequilibrium that included all ancestries, we weighted each ancestry in PAGE by the actual sample size and added in the ARIC sample but used the sample size from the GIANT consortium by trait. All analyses were run assuming one causal variant. The cumulative 95% credible set was calculated from the estimated posterior probabilities.