In EA, no GWS findings were identified. In the trans-ancestral meta-analysis (EA+AA), consistent with prior GWAS, rs1229984 in ADH1B was significantly associated with AD (p = 1.72E-8). In addition, a novel GWS locus was also identified on chromosome 1 (rs61826952, p=8.42E-11) in the EA+AA analysis. Both the EA (p=7.73E-6) and AA (p=1.50E-07; results available upon request) subsamples contributed to the finding, with the same direction of effect. Conditional analyses confirmed that there were independent associations in the ADH1B region but not in the chromosome 1 region (Supplemental Figure 5A, 5C).
