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Chunk #25 — Discussion

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Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.
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Our large sample size allowed us to identify and study 17 distinct cell types in the human caudate nucleus; most correspond well to a recent basal ganglia cell-type atlas of the human brain50. We identified rare interneuron clusters, as well as microglia and oligodendrocytes subtypes not identified in that atlas. Our large caudate-specific atlas sheds more light on the two astrocyte subtypes identified therein.