that were associated with at least two disorders, and 23 pleiotropic variants associated with four or more disorders. This included a variant (rs8084351) in the DCC gene associated with all 8 disorders and a variant (rs7193263) in the RBFOX1 gene associated with all disorders except anorexia nervosa. These genes are also biologically plausible candidates for neuropsychiatric risk given the role of the DCC gene in axonal growth during neurodevelopment (Bendriem & Ross, 2017) and of RBFOX1 in synapse formation (Hamada, Ito, Iwamoto, Morishita, Tabata, & Nagata, 2015). In the most recent cross-disorder genomic effort, 152 pleiotropic variants were identified across 11 psychiatric disorders (Grotzinger et al., 2020).
