interpretation of the functional effect of the S29N polymorphism (rs28399435) that defines the *14 allele. As previously reported [24], and supported by our observations, this polymorphism is in complete linkage disequilibrium with the minor allele of rs1137115 (51A). Yet we find the activity of the *14 allele consistent with full enzymatic function, similar to previous reports [31], and significantly different from other rs1137115A (51A) haplotypes. This suggests that the minor allele of rs28399435 (86A) has lower linkage disequilibrium with the polymorphisms causing reduced efficiency of other rs1137115A (51A) alleles, or represents a compensatory change that cancels out otherwise reduced CYP2A6 activity.
