care were obtained using RMA[54] applied to sample probe values inside exons. RDme/ac were identified by computing a modified t-statistic for each probe and then significant levels of agreement across 1000 bp regions. Enrichment of RDac and RDme was determined by comparing base-pair overlap of these regions with overlap of randomly selected RDac/RDme (see Methods S1 for details). All microarray data are MIAME compliant and the raw data have been deposited in Gene Expression Omnibus (GEO) at NCBI (www.ncbi.nlm.nih.gov/geo/), accession number pending.
