schizophrenia patient [40]. Additionally, it overlaps with a previously reported schizophrenia-associated deletion event at chr15:28.72–30.30 [22],[24], and we also observed a 1.16 Mb deletion in this region in a US patient. This evidence confirms a role for recurrent mutation in this region in schizophrenia susceptibility and indicates that duplications as well as deletions of this region can lead to schizophrenia. Additionally, since no duplication greater than 3 Mb was found in any control subject, there is evidence that duplications of this size are detrimental in general.
