The OR for rs1344706[T] (or the surrogate) was 1.09 in the initial data set and 1.08 in the follow-up data set; P-values were 0.037 in the initial sample and 0.033 in the follow-up sample (Table 1). In the combination of the two data sets, the OR was 1.08 and the P-value was 0.0029 (Table 1). The average control frequency in the combined sample was 0.59, identical to that of the original report.4 We found no evidence of heterogeneity between the study groups (P = 0.66, Supplementary Table 1) and no indication that we should reject the multiplicative model for the full model (P = 0.95 for the initial sample, P = 0.79 for the follow-up sample).
