In line with previous studies4,7,8, our PRS analysis confirmed the genetic overlap of MD with outcomes related to suicidality spectrum. However, we did not find any interactive effect between MD PRS and polysubstance dependence in the context of SI. This could be due to the fact that the genetic variance of GWAS-identified loci appears to be minimally explained by gene-by-environment interactions50. This scenario would support the need of GEWIS to identify alleles responsible to moderate the effect of environmental risk factors.
