CHCs and PVBCs are implicated in the pathophysiology of schizophrenia (Gonzalez-Burgos et al., 2015), and mental disorders likely result from altered neural connectivity rooted in deficient cell types. Key transcription profiles of increasing number of neuron types will facilitate identifying homologous cell types across species through conserved genetic features, linking altered gene expression to aberrant cellular and circuit properties, and discovering therapeutic targets to ameliorate circuit deficits.
