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Chunk #3 — Introduction

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Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.
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(NPY-LI) immunoreactivity in the cingulated cortex and nucleus accumbens (Wahlestedt et al., 1991). In the same rat strain NPY-LI immunoreactivity was found to be expressed in the dentate gyrus, a region of the hippocampus where this expression is not typically found, after a cocaine-induced seizure (Goodman and Slovieter, 1993). These results suggest that NPY may also play a role in response to cocaine.