Chunk #12 — The functional spectrum of human variation

Source

An integrated map of genetic variation from 1,092 human genomes.

Embedded

yes

Text

Purifying selection can also affect population differentiation if its strength and efficacy vary among populations. Although the magnitude of the effect is weak, nonsynonymous variants consistently show greater levels of population differentiation than synonymous variants, for variants of frequency less than 10% (Fig. S13).