amplitude and specific genes or chromosomal loci (Begleiter, et al., 1998; Chen, et al., 2010; Comings, Dietz, Johnson, & MacMurray, 1999; Hill, et al., 1998; Johnson, et al., 1997; Porjesz & Rangaswamy, 2007; Williams, et al., 1999; Wright, et al., 2008). However, in the absence of replication of these P300 candidate gene reports, it would be premature to conclude that we have a solid lead on the molecular genetic basis of P300.