and miniature GABAergic IPSCs allows investigators to determine whether the frequency of synaptic events is altered (a likely presynaptic change), or whether the amplitude is affected (likely a postsynaptic change). Such analyses have consistently shown that sISPC and mIPSC frequencies are increased at EtOH concentrations associated with intoxication, at least in the amygdala, cerebellum, hippocampus and VTA (Ariwodola and Weiner 2004; Zhu and Lovinger 2006; Theile et al. 2008; Roberto et al. 2003; Kelm et al. 2007). These effects are rapid at onset and rapidly reversible following EtOH removal from tissue.
