a lack of such studies. There is expectation of some progress with future studies that consider these pitfalls. Some of these studies are ongoing or at the stage of recruiting subjects [108]. In the interim, it is very difficult to draw a definitive conclusion in relation to the use of cannabinoids for treatment of depression and anxiety. Nevertheless, a common conclusion is that short-term judicious use of cannabis or derivatives lower in THC and higher in CBD may be beneficial in reducing anxiety and depression in different disorders. However, the long-term prospect of using such cannabis-based medicinal preparations may need much more careful scrutiny as it may result in the converse of the desired effect. In addition, the possibility of inducing cannabis use disorder or addiction to cannabis and cannabinoid preparations rich in THC is a distinct possibility that should not be overlooked among certain patients, especially since the prevalence of such disorders is high and rising [144]. CBD-enriched preparations appear to show a more consistent, beneficial effect in ameliorating mood under different conditions, which could present some promise for future use in mood-related disorders. Most studies from cannabis abusers have shown that high concentrations of THC and high ratios
