The rgs with cannabis use disorder and cannabis use were significantly different for 12 of the 22 traits compared (figure 2, appendix p 18). Cannabis use5 and cannabis use disorder were positively genetically correlated with liability to smoking initiation, schizophrenia, major depressive disorder, risk tolerance, and the Townsend Deprivation Index. Cannabis use5 was positively genetically correlated with educational achievement and later age at birth of first child, and negatively with BMI. In contrast, cannabis use disorder was genetically correlated with low education attainment, early age at birth of first child, and high BMI. Liability to cannabis use disorder was genetically correlated with nicotine dependence (rg0·48, p=1·35 × 10−9), whereas the genetic correlation of this trait with cannabis use was not significant (p=0·44). In contrast, cannabis use was significantly genetically correlated with chronotype (rg −0·24, p=6·40 × 10−19), whereas cannabis use disorder showed no significant correlation with this trait (p=0·18). Conditioning the rg of cannabis use disorder on cannabis use loci (with p<0·001) made little difference in the magnitude of the rgs (appendix p 18).
