Very limited information is available regarding the epigenetic changes associated with other addiction disorders. A study of OD in 220 EA women identified differentially methylated CpG sites in genes involved in chromatin remodelling, DNA binding, cell survival, and cell projection147. A genome-wide DNA methylation analysis of 48 heavy cannabis users confirmed the association of AHRR and F2RL3 genes with tobacco smoking in cannabis users and, for users of cannabis only, identified nominally significant methylation changes enriched for neuronal signalling (glutamatergic synapse and long-term potentiation) and cardiomyopathy148. But results from small studies such as these warrant cautious interpretiation.
