Chunk #19 — Magnetic Resonance Spectroscopy

Source

Neuroimaging in alcohol use disorder: From mouse to man.

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In animals, a relatively large body of literature demonstrates that acute ethanol, at concentrations associated with intoxication, potentiates GABAA receptor function and GABA release (e.g., Lobo & Harris, 2008; McCool, Frye, Pulido, & Botting, 2003; Olsen, Hanchar, Meera, & Wallner, 2007) while inhibiting glutamate NMDA receptors (Criswell, Ming, Griffith, & Breese, 2003; Dildy & Leslie, 1989; Hoffman, Rabe, Moses, & Tabakoff, 1989; Lovinger, White, & Weight, 1989). Synaptic responses mediated by NMDA receptors, including extracellular glutamate levels (Carboni, Isola, Gessa, & Rossetti, 1993; Moghaddam & Bolinao, 1994) are also reduced by acute EtOH (Lovinger, White, & Weight, 1990; Morrisett & Swartzwelder, 1993; Roberto et al., 2004).