The current results indicate that the SRE LR value accounted for up to 60% of the ability of alcohol challenge LR’s to predict future heavier drinking. These data suggest that the less expensive and more widely applicable SRE may function as an acceptable proxy for alcohol challenges in both the search for genes contributing to LR, as well as the manner in which LR relates to additional life characteristics in structural equation models. As expected based on the differences in methods used, the overlap between these two LR measures was substantial, but not perfect, and additional study will be needed to explore the meaning of the remaining ∃40% of the variance of outcome.
