brain region called the central nucleus of the amygdala. Intriguingly, when molecules that specifically could inhibit the GABRA2 gene (i.e., α2 silent RNA [siRNA]) were introduced into the central amygdala, even the P animals no longer demonstrated binge drinking for a short period of time, and this effect correlated with a significant reduction of α2 levels. This effect did not occur when siRNA for another receptor subunit (i.e., α1 siRNAs) was used or when α2 siRNA was introduced in other control regions of the brain.
