et al., 2011). Further studies have demonstrated change in the receptor function in response to nicotine agonists given this amino acid change in the a5 nicotinic receptor subunit (Bierut et al., 2008a; Brown et al., 2007). Growing evidence indicates that rs16969968 in CHRNA5 is a predictor for smoking cessation in some circumstances and predicts a delay in successful smoking cessation (Baker et al., 2009; Bergen et al., 2013; Chen et al., 2012, 2015; Freathy et al., 2009; Munafo et al., 2011; Sarginson et al., 2011; Zhu et al., 2014).
