Adding further evidence to the relevance of genetic factors identified in the current study are the results of our replication efforts. First, we examined genes with q<0.05 in an independent sample consisting of Finnish twins assessed for alcohol problems at age 14, and found a trend toward significance for TBCE. Furthermore, as reported by Salvatore and colleagues [30], polygenic risk scores derived using SNP weights from the ALSPAC sample were significantly correlated with alcohol problems in the Finnish sample. Thus, we are confident that despite the small magnitude of effects, we are capturing some degree of “true” genetic risk.
