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Chunk #48 — 3. Results — 3.5 Effects of alcohol on subjective measures

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Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism.
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Figure 2 shows peak data for selected subjective measures. Beck Depression scores were significantly higher in the luteal phase compared to the follicular phase [Phase effect; F(1,43) = 7.59; p <0.01] and were increased by alcohol administration [Dose effect; F(2,86) = 6.69; p <0.004]. There was also a trend for alcohol to increase Beck Depression scores more in FHP women than FHN women during the luteal phase (Phase × Dose × Group interaction; p<0.09). Similarly, FHP women had slightly higher Depression-Dejection scores than FHN women during the luteal phase [Phase × Group interaction; F(1,43) = 5.33; p <0.03]. Figure 3 also shows that alcohol produced dose-related increases on ratings of Good Drug Effect [Dose effect; F(2,86) = 72.21; p <0.0001], with the high dose of alcohol increasing ratings more during the luteal phase compared to the follicular phase [Phase × Dose interaction; F(2,86) = 4.07; p <0.03]. A similar pattern was observed for ratings of Drug Liking, but was not statistically significant.