Contrasting with these results, the largest study of EEG power and peak frequency to date (Malone et al., 2014) did not yield genome‐wide significant hits. They did report, however, significant contribution of common SNP variants to the heritability using random‐effects modeling (Yang et al., 2010). This suggests that statistical power to detect genome‐wide significant effects is limited, as the effects of single genetic variants on complex, multifactorial phenotypes such as brain activity are expected to be very small. Therefore, our first aim was to extend previous studies by performing a meta‐analysis of genome‐wide association studies (GWAS) of oscillatory power across standard frequency bands, yielding the largest EEG GWAS study to date. To further understand these findings, we also estimated SNP‐based heritability using LD score regression (Bulik‐Sullivan et al., 2015b).
