Chunk #19 — Results — bZIP transcription factors are implicated in increased astrocyte reactivity in AUD

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Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.

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In astrocytes, LINGER identified six transcription factors implicated in regulating AUD-associated differences in both expression and chromatin accessibility of their target genes. These transcription factors included JUND (JunD proto-oncogene), which had increased regulatory activity in individuals with AUD (Supplementary Fig. 7d, e).